Search for: All records

Abstract The relationship between infection prevalence and host age is informative because it can reveal processes underlying disease dynamics. Most prior work has assumed that age‐prevalence curves are shaped by infection rates, host immunity and/or infection‐induced mortality. Interactions between parasites within a host have largely been overlooked as a source of variation in age‐prevalence curves.We used field survey data and models to examine the role of interspecific interactions between parasites in shaping age‐prevalence curves. The empirical dataset included quantification of parasite infection prevalence for eight co‐occurring trematodes in over 15,000 snail hosts. We characterized age‐prevalence curves for each taxon, examined how they changed over space in relation to co‐occurring trematodes and tested whether the shape of the curves aligned with expectations for the frequencies of coinfections by two taxa in the same host. The models explored scenarios that included negative interspecific interactions between parasites, variation in the force‐of‐infection (FOI) and infection‐induced mortality that varied with host age, which were mechanisms hypothesized to be important in the empirical dataset.In the empirical dataset, four trematode parasites had monotonic increasing age‐prevalence curves and four had unimodal age‐prevalence curves. Some of the curves remained consistent in shape in relation to the prevalence of other potentially interacting trematodes, while some shifted from unimodal to monotonic increasing, suggesting release from negative interspecific interactions. The most common taxa with monotonic increasing curves had lower co‐infection frequencies than expected, suggesting they were competitively dominant. Taxa with unimodal curves had coinfection frequencies that were closer to those expected by chance.The model showed that negative interspecific interactions between parasites can cause a unimodal age‐prevalence curve in the subordinate taxon. Increases in the FOI and/or infection‐induced mortality of the dominant taxon cause shifts in the peak prevalence of the subordinate taxon to a younger host age. Infection‐induced mortality that increased with host age was the only scenario that caused a unimodal curve in the dominant taxon.Results indicated that negative interspecific interactions between parasites contributed to variation in the shape of age‐prevalence curves across parasite taxa and support the growing importance of incorporating interactions between parasites in explaining population‐level patterns of host infection over space and time. Read the freePlain Language Summaryfor this article on the Journal blog. 

Haptic devices enable communication via touch, augmenting visual and auditory displays, or by offering alternative channels of communication when vision and hearing are unavailable. Because of the different types of haptic stimuli that are perceivable by users — vibration, skin stretch, pressure and temperature, among others — devices can be designed to communicate complex information by delivering multiple types of haptic stimuli simultaneously. These multi-sensory haptic devices are often designed to be wearable and have been developed for use in a wide variety of applications, including communication, entertainment and rehabilitation. Multi-sensory haptic devices present unique challenges to designers because human perceptual acuity can vary widely depending on the wearable location on the body and/or the heterogeneity in human perceptual performance, particularly when multiple cues are presented simultaneously. Additionally, packaging haptic systems in a wearable form factor presents its own engineering challenges such as cue masking, device mounting and actuator capabilities, among others. Thus, in this Review, we discuss the state-of-the-art and specific obstacles present in the field to produce multi-sensory devices that enhance the human capacity for haptic interaction and information transmission. 

Thin, flexible sheets can be patterned and bonded to form internal fluidic networks, which enable actuation, sensing, and control, but failure of these sheet-based systems—and how to take advantage of this failure—remains relatively unexplored. Here, we examine this concept using heat-sealable textiles as a material platform. We determine the effects of geometry and material processing on bond strength and burst pressure; these findings can ensure a sheet-based fluidic system is sufficiently robust for a given use case. Building on this framework, we introduce a fuse-like component into which failure is deliberately programmed. In addition to limiting damage in the case of overpressurization, we leverage this programmed failure to enable distinct capabilities including (1) the binary selection of operating modes and (2) the sequencing of a series of tasks with a single pressure input. These findings will facilitate the development of more intelligent sheet-based fluidic systems. 

Silicone elastomers exhibit extraordinary compliance, positioning them as a material of choice for soft robots and devices. To accelerate curing times of platinum-catalyzed silicone elastomers, researchers have employed elevated temperatures; however, knowledge of the requisite duration for curing at a given temperature has remained limited to specific elastomers and has relied primarily on empirical trends. This work presents an analytical model based on an Arrhenius framework coupled with data from thermo-rheological experiments to provide guidelines for suitable curing conditions for commercially available addition-cured platinum-catalyzed silicone elastomers. The curing reaction exhibits self-similarity upon normalizing to a dimensionless reaction coordinate, allowing quantification of the extent of curing under arbitrary time-varying thermal conditions. Mechanical testing revealed no significant changes in properties or performance as a result of thermally accelerated curing. With this framework, higher throughput of elastomeric components can be achieved, and the design space for elastomer-based manufacturing can be developed beyond conventional casting. 

Vibration is a widely used mode of haptic communication, as vibrotactile cues provide salient haptic notifications to users and are easily integrated into wearable or handheld devices. Fluidic textile-based devices offer an appealing platform for the incorporation of vibrotactile haptic feedback, as they can be integrated into clothing and other conforming and compliant wearables. Fluidically driven vibrotactile feedback has primarily relied on valves to regulate actuating frequencies in wearable devices. The mechanical bandwidth of such valves limits the range of frequencies that can be achieved, particularly in attempting to reach the higher frequencies realized with electromechanical vibration actuators ( > 100 Hz). In this paper, we introduce a soft vibrotactile wearable device, constructed entirely of textiles and capable of rendering vibration frequencies between 183 and 233 Hz with amplitudes ranging from 23 to 114 g . We describe our methods of design and fabrication and the mechanism of vibration, which is realized by controlling inlet pressure and harnessing a mechanofluidic instability. Our design allows for controllable vibrotactile feedback that is comparable in frequency and greater in amplitude relative to state-of-the-art electromechanical actuators while offering the compliance and conformity of fully soft wearable devices. 

Vibration is ubiquitous as a mode of haptic communication, and is used widely in handheld devices to convey events and notifications. The miniaturization of electromechanical actuators that are used to generate these vibrations has enabled designers to embed such actuators in wearable devices, conveying vibration at the wrist and other locations on the body. However, the rigid housings of these actuators mean that such wearables cannot be fully soft and compliant at the interface with the user. Fluidic textile-based wearables offer an alternative mechanism for haptic feedback in a fabric-like form factor. To our knowledge, fluidically driven vibrotactile feedback has not been demonstrated in a wearable device without the use of valves, which can only enable low-frequency vibration cues and detract from wearability due to their rigid structure. We introduce a soft vibrotactile wearable, made of textile and elastomer, capable of rendering high-frequency vibration. We describe our design and fabrication methods and the mechanism of vibration, which is realized by controlling inlet pressure and harnessing a mechanical hysteresis. We demonstrate that the frequency and amplitude of vibration produced by our device can be varied based on changes in the input pressure, with 0.3 to 1.4 bar producing vibrations that range between 160 and 260 Hz at 13 to 38 g, the acceleration due to gravity. Our design allows for controllable vibrotactile feedback that is comparable in frequency and outperforms in amplitude relative to electromechanical actuators, yet has the compliance and conformity of fully soft wearable devices.